作为重要的免疫效应细胞,巨噬细胞还具有抗原提呈功能.若能在利用其免疫效应细胞功能的同时,充分发挥其抗原提呈功能,将有可能给肿瘤的治疗提供新的思路;本研究通过将GM-CSF基因转染小鼠腹腔巨噬细胞以增强其双重功能,再将其接种至肿瘤局部治疗皮下接种的荷瘤小鼠或经肿瘤抗原致敏后通过静脉注射治疗实验性肿瘤肺转移小鼠,观察了其疗效并初步探讨了其免疫机制. As an important immune effector cell, macrophages also have an antigen presenting function. If they can use their immune effector cells function and fully display their antigen presentation function, it will be possible to provide new ideas for the treatment of tumors; Study on GM-CSF gene transfection into mouse peritoneal macrophages to enhance its dual function, and then inoculate it into the tumor local treatment of subcutaneously inoculated tumor-bearing mice or sensitized by tumor antigens to treat experimental tumors by intravenous injection Lung metastasis mice, observed its efficacy and preliminary explored its immune mechanism.