据Shim在夏威夷研究,华人婴儿胆道闭锁发病率较日本、菲律宾及白人婴儿为高,新生儿肝炎更为常见,但多数病例的病因及自然病史不明。病人和方法台湾大学医院于1979年6月至1984年6月,收治中等度新生儿肝炎100例,随访了56例,45例作CMV血清检查,内41例同时尿培养CMV。22例(49%)有感染证据:14例血清阳性,其中尿培养8例阳性,2例阴性,4例未定。8倒尿培养阳性而血清学阴性。23倒无CMV感染实验室证据。56例中2例死于非肝炎病。余54例分成预后较差和恢复两大组。第1组9例,7例死于肝病或肝病合并败血症,死前黄疸持续不退;1例于4岁病死,6例死于11个月龄内,其中3例是暴发性经过。于2至4月龄间死亡,内2例为CMV感染及G6PD缺乏合并溶血性贫血。存活2例伴肝硬化,1例黄疸于11个月龄 According to Shim’s study in Hawaii, the incidence of biliary atresia among Chinese infants is higher than that of Japanese, Filipino and white infants. Neonatal hepatitis is more common, but the etiology and natural history of most cases are unknown. Patients and Methods Taiwan University Hospital from June 1979 to June 1984, 100 cases of moderate neonatal hepatitis were treated, followed up 56 cases, 45 cases of CMV serum examination, 41 cases of simultaneous culture of CMV. Twenty-two patients (49%) had evidence of infection: 14 were seropositive, including 8 in urine culture, 2 negative, and 4 undetermined. 8 inverted urine culture positive and serological negative. 23 inverted laboratory evidence of CMV infection. Two of the 56 patients died of non-hepatitis. 54 cases were divided into poor prognosis and recovery of the two major groups. In group 1, 9 patients died of hepatic disease or liver disease with sepsis. Jaundice persisted until death. One patient died of disease at the age of 4 and 6 died of 11 months of age. Three of the patients died of fulminant disease. Two to four months of age died, two cases of CMV infection and G6PD lack of combined hemolytic anemia. Survival in 2 cases with cirrhosis, 1 case of jaundice at 11 months of age