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采用体外放射配体受体结合法测定３－酮－地索高诺酮（ＫＤＧ）与兔子宫胞浆雌激素受体（ＥｃＲ）、孕激素受体（ＰｃＲ）和大鼠腹侧前列腺胞浆雄激素受体（ＡｃＲ）结合的亲和力，并以左旋１８－甲基炔诺酮（ＬＮＧ）作对照，从受体水平探讨ＫＤＧ对当体激素受体的选择性。结果表明：ＫＤＧ对ＰｃＲ有很高的亲和力，是ＬＮＧ的１．５倍；对ＡｃＲ的亲和力很低，仅为ＬＮＧ的０．７４倍；对ＥｃＲ几乎没有亲和力，受体亲和力选择系数也明显高于ＬＮＧ。由此可见，在ＬＮＧ甾核结构中Ｃ１１位引入次甲基合成的ＫＤＧ，其受体亲和力选择性更专一。
In vitro radioligand-receptor binding assay was used to determine the relationship between KDG and the uterine cytosolic estrogen receptor (EcR), progesterone receptor (PcR) and rat ventral prostate cytoplasm Androgen receptor (AcR) binding affinity, and the use of levonorgestrel (LNG) as a control, from the receptor level to explore the KDG when the hormone receptor selectivity. The results showed that: KDG has a high affinity for PcR, which is 1.5 times that of LNG; its affinity for AcR is very low, only 0.74 times that of LNG; almost no affinity for EcR and a significantly high selectivity for receptor affinity In LNG. Thus, introduction of methine-synthesized KDG at the C11 position in the LNG steroid nuclear structure is more specific for its receptor affinity selectivity.