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为探讨喉上皮癌前病变及癌组织 p53蛋白的表达与细胞增殖活性的关系 ,应用免疫组化技术对 11例喉上皮单纯性增生 (SHE)、32例非典型性增生 (AHE)及 4 2例喉鳞癌 (LSCC)进行研究。结果显示 :31 2 5%及 52 38%的AHE及LSCCp53蛋白阳性表达 ;p53蛋白阳性的AHE及LSCC ,其细胞增殖活性均较阴性者高 (P <0 0 5)。结果提示 :p53基因的突变以及由此导致的细胞异常增殖与喉癌的发生有密切关系 ,联合检测 p53蛋白表达及细胞增殖活性对判断喉AHE的发展趋势及LSCC的恶性程度有重要的参考价值。
To investigate the relationship between p53 protein expression and cell proliferation activity in laryngeal precancerous lesions and cancerous tissues, 11 cases of laryngeal epithelial simple hyperplasia (SHE), 32 cases of atypical hyperplasia (AHE) and 42 Cases of laryngeal squamous cell carcinoma (LSCC) were studied. The results showed that 31 52% and 52 38% of AHE and LSCCp53 protein positive expression; p53 protein positive AHE and LSCC, the cell proliferation activity was higher than the negative (P <0 05). The results suggest that the mutation of p53 gene and the abnormal cell proliferation are closely related to the occurrence of laryngeal carcinoma. The combined detection of p53 protein expression and cell proliferation activity has important reference value for judging the developmental trend of laryngeal AHE and the malignancy of LSCC .