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目的探讨p16b、cl-2基因在大肠癌发生、发展中的作用以及临床中的意义。方法运用免疫组化技术检测大肠癌及腺瘤中p16、bcl-2基因蛋白的表达。结果p16基因蛋白阳性表达率在大肠癌及腺瘤中分别为35.90%、77.27%(P<0.01);bcl-2基因蛋白阳性表达率在大肠癌及腺瘤中分别为61.53%、72.72%(P>0.05)。p16与bcl-2基因蛋白表达在大肠癌中有相关关系,并与肿瘤分化程度、浆膜侵润、淋巴结转移有明显相关性,与年龄、性别、Dukes分期无相关性。结论p16基因的失活与bcl-2基因的过表达在大肠癌的发生、发展中起重要作用;大肠腺瘤是一种重要的癌前病变;对大肠癌及腺瘤进行p16、bcl-2基因检测有助于大肠癌的早期诊断及预后评估。
Objective To investigate the role of p16b and cl-2 in the genesis and progression of colorectal cancer and its clinical significance. Methods Immunohistochemistry was used to detect the expression of p16 and bcl-2 protein in colorectal carcinoma and adenoma. Results The positive rates of p16 protein in colorectal carcinoma and adenoma were 35.90% and 77.27%, respectively (P <0.01). The positive rates of bcl-2 protein in colorectal carcinoma and adenoma were 61.53% and 72.72% P> 0.05). The expression of p16 protein and bcl-2 protein in colorectal cancer were correlated with tumor differentiation, serosa invasion and lymph node metastasis, but not with age, sex and Dukes stage. Conclusion Inactivation of p16 gene and overexpression of bcl-2 gene play an important role in the carcinogenesis and progression of colorectal cancer. Colorectal adenoma is an important precancerous lesion; p16, bcl-2 Genetic testing contributes to the early diagnosis and prognosis of colorectal cancer.