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目的探讨外周环境饮用水中碘含量与布-加综合征发病的关系。方法选择1995—2004年菏泽市立医院等5家医院收治的居住地为山东菏泽且可以查到地址的342例布-加综合征患者为研究对象,对其性别、年龄、饮用水中碘含量进行描述性分析;以2003年山东省菏泽地区各乡镇的水碘中位数为依据,建立菏泽地区布-加综合征患者空间分布图,并对水碘与布-加综合征关系进行空间统计分析;以2000年第五次人口普查数据为依据,计算菏泽各县布-加综合征发病率,并对各县布-加综合征发病率与水碘值中位数进行线性相关分析。结果在342例布-加综合征患者中,女性126例,占36.84%;男性216例,占63.16%,男女性别比为1.71:1。患者年龄为(40.30±12.97)岁,300例患者分布于25～64岁年龄段。菏泽地区布-加综合征患者所在乡镇的水碘含量范围为12.62～681.21μg/L,中位数为262.05μg/L。89.18%患者所在乡镇的水碘值>150μg/L,水碘浓度与布-加综合征发病率呈正相关(r=0.846,P=0.008)。结论布-加综合征的发生可能与饮用水中碘含量过高有关,高碘在布-加综合征发病过程中的作用还有待进一步的研究。
Objective To investigate the relationship between the iodine content in peripheral drinking water and the incidence of Budd-Chiari syndrome. Methods 342 patients with Budd-Chiari syndrome who lived in Heze Municipal Hospital and other five hospitals in Heze City, Shandong Province from 1995 to 2004 were selected as study subjects. Their sex, age and iodine content in drinking water Descriptive analysis; based on the median of water iodine in each township of Heze area in Shandong province in 2003, the spatial distribution map of patients with Budd-Chiari syndrome in Heze area was established, and the spatial statistical analysis was performed on the relationship between water iodine and Budd-Chiari syndrome ; Based on the fifth census data of 2000, the incidence of Budd-Chiari syndrome was calculated in Heze counties. The incidence of Budd-Chiari syndrome and the median of water iodine value in each county were linearly analyzed. Results Of the 342 patients with Budd-Chiari syndrome, 126 were female (36.84%), 216 were male (63.16%), and the ratio of male to female was 1.71: 1. The patient’s age was (40.30 ± 12.97) years old and 300 patients were distributed between 25-64 years old. Water iodine content of township of patients with Budd-Chiari syndrome in Heze ranged from 12.62 to 681.21 μg / L, with a median of 262.05 μg / L. The water iodine value of 89.18% of the township patients was> 150μg / L, and the iodine concentration was positively correlated with the incidence of Budd - Chiari syndrome (r = 0.846, P = 0.008). Conclusions The occurrence of Budd-Chiari syndrome may be related to the high iodine content in drinking water. The role of high iodine in the pathogenesis of Budd-Chiari syndrome remains to be further studied.