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目的:探讨肝硬变并自发性细菌性腹膜炎(SBP)病人腹水中白细胞介素8(IL-8)水平的变化和临床意义。方法:采用双抗体夹心ELISA法测定48例肝硬变腹水病人血清和腹水中IL-8的含量。结果:在28例SBP病人血清和腹水中IL-8水平明显高于20例漏出性腹水病人(P<0.01);SBP病人腹水中IL-8的水平随着感染被控制而明显下降(P<0.01)。结论:检测腹水中IL-8的含量有助于SBP的诊断和疗效分析。
Objective: To investigate the changes and clinical significance of interleukin-8 (IL-8) in patients with cirrhosis and spontaneous bacterial peritonitis (SBP). Methods: The content of IL-8 in serum and ascites of 48 patients with liver cirrhosis ascites was measured by double antibody sandwich ELISA. Results: The levels of IL-8 in serum and ascites of 28 patients with SBP were significantly higher than those of 20 patients with ascites (P <0.01). The level of IL-8 in ascites of patients with SBP was significantly decreased as the infection was controlled (P < 0.01). Conclusion: Detection of IL-8 in ascites is helpful for the diagnosis and treatment of SBP.