本文报道蒿甲醚实验治疗小鼠血吸虫病时,对其体内血吸虫及宿主肝脏的组织学及组织化学改变所作观察结果。发现蒿甲醚不仅能引起肝移虫的体表、肠管及生殖器官等明显退化变性,而且具有明显的杀血吸虫成虫作用,其杀雌虫作用尤为迅速、强烈。该药可使肝移虫体的糖原、碱性磷酸酶、RNA及酚酶明显减少或消失;雌虫出现这些变化较雄虫为早。同 This article reports the artemether experimental treatment of schistosomiasis in mice, its in vivo schistosomiasis and host liver histological and histochemical observations made. It was found that artemether could not only cause obvious degeneration and degeneration of body surface, intestine and reproductive organs, but also had obvious schistosomiasis killing effect. The killing effect on female was rapid and intense. The drug can cause liver worms body glycogen, alkaline phosphatase, RNA and phenolic enzymes significantly reduced or disappeared; females appear these changes earlier than the male. with