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前列腺素(简称 PG)参与许多不同类型的腹泻。已经证明:人们口服 PG 后,可发生腹部痉挛和水泻,并使肠道中的标记物通过加速、直肠和乙状结肠的推进性压力波的数目增多。前列腺素介入性腹泻(Pro-taglandin-mediated diarrhea)的机制涉及小肠平滑肌的收缩增加,从而缩短通过时间。有人认为 PG引起的水和电解质的移动非常近似霍乱外毒素对小肠的作用。曾有许多分别的报导,均企图应用 PG 合成抑制剂治疗 PG 介入性腹泻。例如实验发现,indomthein、阿斯匹灵、肉豆蔻等在玻皿内能抑制 PG的合成。
Prostaglandins (PGs) are involved in many different types of diarrhea. It has been shown that after oral administration of PG, abdominal cramps and watery diarrhea can occur and the markers in the intestine are accelerated. The number of propulsive pressure waves in the rectum and sigmoid colon is increased. The mechanism of prostaglandin-mediated diarrhea involves an increase in the contraction of the small intestine smooth muscle, thereby shortening the transit time. It is thought that the movement of water and electrolyte caused by PG is very similar to the effect of cholera exotoxin on the small intestine. There have been many separate reports on attempts to treat PG-associated diarrhea using PG synthesis inhibitors. For example, the experiment found indomthein, aspirin, nutmeg and other inhibitory PG in the glass plate synthesis.