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多药耐药(multidrug resistance,MDR)是肿瘤的重要耐药机制,是肿瘤化疗失败的主要原因之一。MDR是指由一种药物诱发,但同时又对其他多种结构和作用机制迥异的抗癌药物产生交叉耐药[1]。近年来,人们对肿瘤多药耐药机制进行了深入的研究,耐药的机制主要涉及以下几个方面:(1)膜糖?
Multidrug resistance (multidrug resistance, MDR) is an important drug resistance mechanism of the tumor, is one of the main reasons for the failure of chemotherapy in the tumor. MDR refers to a drug-induced, but at the same time on a variety of other structures and mechanisms of action of different anticancer drugs have cross-resistance [1]. In recent years, people have carried out in-depth research on the mechanism of multi-drug resistance in tumors, and the mechanisms of drug resistance mainly involve the following aspects: (1) membrane sugar?