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目的 :探讨 2型糖尿病 (DM)患者尿TGF - β1、Ⅳ胶原 (Ⅳ -C)含量的变化及其临床意义。方法 :6 1例 2型DM患者根据尿白蛋白排泄率 (UAER)分为正常白蛋白尿组 (Ⅰ )、微量白蛋白尿组 (Ⅱ )和大量白蛋白尿组 (Ⅲ ) ,分别检测各组患者尿TGF - β1和Ⅳ -C的含量 ,并与 30例正常对照组 ((NC)进行比较。结果 :糖尿病各组患者尿TGF - β1和Ⅳ -C含量显著高于正常对照组 (p <0 0 5 ) ,且随着UAER增加其水平亦呈逐年递增趋势 ,组间比较差异显著 (p <0 0 1)。相关分析表明 ,尿TGF - β1与尿Ⅳ -C、UAER及尿α1-m之间呈显著正相关 (p <0 0 1)。结论 :TGF - β1和Ⅳ -C在糖尿病肾病 (DN)的发生发展中起着重要作用。测定DM患者尿TGF- β1和Ⅳ -C的含量 ,不仅可作为诊断DN早期肾损害较敏感的指标 ,还将有助于监测、判断DN的病程进展
Objective: To investigate the changes of urinary TGF - β1, Ⅳ collagen (Ⅳ -C) in patients with type 2 diabetes (DM) and its clinical significance. Methods: Sixty-one patients with type 2 DM were divided into normal albuminuria group (Ⅰ), microalbuminuria group (Ⅱ) and large albuminuria group (Ⅲ) according to urinary albumin excretion rate (UAER) The urinary levels of TGF - β1 and Ⅳ - C were compared with those of 30 normal controls (NC) .Results: The urinary levels of TGF - β1 and Ⅳ - C in diabetic patients were significantly higher than those in normal controls (p <0 0 5), and the level of UAER increased year by year as well, with significant difference between the two groups (p <0.01) .The correlation analysis showed that urinary TGF - β1 and urine Ⅳ -C, UAER and urine α1 (P <0.01) .Conclusion: TGF - β1 and Ⅳ - C play an important role in the development of diabetic nephropathy.Determination of urinary TGF - β1 and Ⅳ - C content, not only as early diagnosis of DN nephropathy more sensitive indicators, will also help monitor and determine the course of DN progression