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JAMA杂志于2012年4月4日发表的一项药物流行病学研究表明,使用氟喹诺酮类药物或可增加视网膜脱落的风险[1]。该研究共纳入英国哥伦比亚地区2000年1月至2007年12月眼科门诊患者989 591例。从中选取视网膜脱落后14 d内行视网膜修复手术的患者为试验组,共4384例,其中未使用氟喹诺酮组3939例(89.8%),使用氟喹诺酮组445例(10.2%)。对试验组每例患者,选取10例年龄匹配而未发生视网膜脱落的受试者作为对照组,共43 840例。使用氟喹诺酮组又分为3个亚组:就诊时正在用药组(145例),近期用药组(就诊前1～7 d用药,12例),既往用药组(就诊前8～365 d用药,288例)。
A pharmacoepidemiological study published on JAMA on April 4, 2012, shows that the use of fluoroquinolones may increase the risk of retinal detachment [1]. The study included 989 591 ophthalmic outpatients from January 2000 to December 2007 in the British Columbia. A total of 4384 patients were enrolled in this study, including 1439 patients (89.8%) without fluoroquinolone group and 445 patients (10.2%) with fluoroquinolone group. For each patient in the experimental group, a total of 43 840 subjects were selected as control subjects in 10 matched age-matched subjects without retinal detachment. Fluoroquinolone group was divided into three subgroups: the treatment group (145 cases), the recent medication group (1-7 days before treatment, 12 cases), the former medication group (8 to 365 days before treatment, 288 cases).