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甲氰咪呱(Cimetidine) 引起急性肝损害在临床上甚为罕见,现将笔者所遇一例报告如下。男患,42岁。因反复发作上腹部饥饿性疼痛伴泛酸2年,加重1天于1989年2月5日入院。无肝、胆疾患等病史,无药物过敏及毒物接触史。查体:心、肺正常,肝脾不肿大,剑突下偏右侧轻度压痛。实验室检查:血、尿、大便常规及肝功能结果均正常,HBsAg、HBeAg、抗HBe、抗HBc均阴性,腹部肝、胆、脾、胰B超结果正常,纤维胃镜示十二指肠球部溃疡。入院后给予Cime-tidine 0.2,一日三次口服,睡前服0.4,用药11天后,患者出现乏力、纳差、全身皮肤骚痒,巩膜中度黄染,肝、脾肋下未触及,肝区轻度叩击痛,四
Cimetidine (Cimetidine) caused acute liver injury is very rare in clinical practice, I now encounter a case report as follows. Male suffering, 42 years old. Due to recurrent upper abdominal hunger pain with pantothenic acid 2 years, one day heavier on February 5, 1989 admission. No liver, gallbladder disease and other medical history, no drug allergies and toxic contact history. Physical examination: heart, lungs normal, liver and spleen is not swollen, mild right xiphoid tenderness. Laboratory tests: blood, urine, stool routine and liver function results were normal, HBsAg, HBeAg, anti-HBe, anti-HBc were negative, abdominal liver, gallbladder, spleen, pancreas B-normal results, fibrous gastroscopy showed duodenal bulb Ulcers. Admitted to hospital after Cime-tidine 0.2, three times a day orally, before going to bed serving 0.4, 11 days after treatment, patients with fatigue, anorexia, systemic skin itching, sclera moderate yellow dye, liver, spleen ribs untouched, liver Mild percussion pain, four