论文部分内容阅读
应用发色底物法测定急性心梗(AMI)患者入院当天、第7天及第14天的血浆组织纤溶酶原激活物(t-PA)及其抑制物(PAI)的活性变化。结果表明:PAI活性在AMI急性发作期及稳定期持续显著高于对照组,而t-PA活性在入院当天明显降低,但于第7天后回升接近于正常水平。再发性心梗患者的t-PA活性明显低于对照组及初发性心梗患者,急性期死亡患者的PAI活性明显升高而t-PA活性极度降低。PAI活性在CPK峰值不同的亚组中无显著差异,提示AMI患者存在着纤溶活性受损,高水平的PAI活性不是一种组织损伤非特异性的急性期反应。
The chromogenic substrate method was used to determine the changes of plasminogen activator (t-PA) and its inhibitor (PAI) in patients with acute myocardial infarction (AMI) on the day of admission, the 7th day and the 14th day. The results showed that the activity of PAI in AMI during acute attack and stable period was significantly higher than that in control group, while the activity of t-PA was significantly decreased on the day of admission, but returned to normal after 7 days. The t-PA activity in patients with recurrent MI was significantly lower than that in controls and patients with newly diagnosed MI, PAI activity in acute death patients was significantly increased and t-PA activity was extremely decreased. There was no significant difference in PAI activity in subgroups with different CPK peak values, suggesting that fibrinolytic activity was impaired in AMI patients. High levels of PAI activity were not a nonspecific acute phase response to tissue injury.