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FK506是一种强效的免疫抑制剂,通过抑制钙神经素的活性抑制白细胞介素2(IL-2)等细胞因子的基因表达,从而发挥免疫抑制作用。动物实验表明FK506能够预防实验性自身免疫性葡萄膜视网膜炎(EAU)的发生或者降低其严重程度。临床治疗证明了FK506对葡萄膜炎,尤其是顽固性内源性葡萄膜炎有较好的治疗效果。副作用主要有肾毒性、胃肠道症状和神经毒性等。通过选择合适的适应证、使用适当的剂量和监测FK506的血药质量浓度,可以取得较好的治疗效果并避免一些副作用的发生。
FK506 is a potent immunosuppressive agent that exerts immunosuppressive effects by inhibiting the activity of calcineurin and inhibiting the gene expression of cytokines such as interleukin 2 (IL-2). Animal experiments show that FK506 can prevent the occurrence or reduce the severity of experimental autoimmune uveoretinitis (EAU). Clinical treatment of FK506 proved that uveitis, especially refractory endogenous uveitis have a better therapeutic effect. Side effects are mainly nephrotoxicity, gastrointestinal symptoms and neurotoxicity. By selecting the appropriate indications, using the appropriate dose and monitoring the plasma concentration of FK506, you can get better treatment and avoid some side effects.