论文部分内容阅读
目的综合分析幽门螺杆菌(Hp)感染与儿童特发性血小板减少性紫癜(ITP)的关系。方法利用计算机及手工检索2000-2010年在中国期刊全文数据库、万方数据库、重庆维普及Pubmed公开发表的关于Hp感染与儿童ITP关系的病例对照研究资料,采用Meta分析方法对所有文献进行综合分析,并计算综合的OR值和95%CI。结果检索共收集相关文献35篇,排除其中研究方法不符合要求的文献,共检索有效文献8篇,其中中文文献6篇,英文文献2篇。ITP组与对照组的Meta分析结果 :OR(95%CI)为1.90(1.44～2.50),合并效应量的检验结果 Z=4.56,P=0.00001。急性ITP组与慢性ITP组的Meta分析结果 :OR(95%CI)为0.74(0.49～1.13),合并效应量的检验结果 Z=1.38,P=0.17。结论 Hp感染与儿童ITP的发病密切相关,但与ITP的类型无关。
Objective To analyze the relationship between Helicobacter pylori (Hp) infection and idiopathic thrombocytopenic purpura (ITP) in children. Methods The data of case-control study on the relationship between Hp infection and children’s ITP published in Chinese Journal Full-text Database, Wanfang Database, Chongqing Weipu and Pubmed from 2000 to 2010 were searched by computer and all the documents were analyzed by Meta-analysis , And calculated the combined OR and 95% CI. A total of 35 articles were collected from the search results, excluding the ones whose research methods did not meet the requirements. Eight valid documents were retrieved, of which 6 were in Chinese and 2 were in English. Meta-analysis results of ITP group and control group: OR (95% CI) was 1.90 (1.44-2.50). The test result of combined effect Z = 4.56, P = 0.00001. The meta-analysis of acute ITP group and chronic ITP group showed that the OR (95% CI) was 0.74 (0.49-1.13) and the combined effect was Z = 1.38 (P = 0.17). Conclusion Hp infection is closely related to the onset of childhood ITP, but not to the type of ITP.