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目的探讨初治和复治肺结核合并肺部感染患者的病原菌分布状况和临床耐药特征。方法研究初治和复治肺结核合并肺部感染患者送检痰标本的细菌培养结果,观察患者的耐药性,结果初治和复治肺结核合并肺部感染患者以革兰阴性菌为主,复治组为59.47%,初治组为52.87%;复治组革兰阳性菌为21.20%,初治组为27.38%;复治组真菌19.33%,初治组19.75%;复治组细菌对左氧氟沙星、莫西沙星及利福平的耐药率较初治组有显著的增加。结论复治肺结核患者的反复治疗导致细菌耐药性增强。
Objective To investigate the distribution and clinical characteristics of pathogens in patients with newly diagnosed and retreated pulmonary tuberculosis complicated with pulmonary infection. Methods The results of bacterial culture in patients with newly diagnosed and retreated pulmonary tuberculosis with pulmonary infection were analyzed. The drug resistance of the patients was observed. The results showed that patients with newly diagnosed pulmonary tuberculosis and pulmonary infection had Gram-negative bacteria, The rate of Gram-positive bacteria in retreatment group was 21.20%, that in initial treatment group was 27.38%, that in retreatment group was 19.33%, and that in initial treatment group was 19.75% , Moxifloxacin and rifampicin than the initial treatment group had a significant increase. Conclusion Repeated treatment of patients with re-treatment of pulmonary tuberculosis results in enhanced bacterial resistance.