目的探讨临床低病毒载量乙型肝炎相关活动性患者在用阿德福韦酯治疗前后的治疗效果观察。方法选取2012年8月—2013年8月我校附属人民医院消化内科收治的100例乙型病毒性肝炎肝硬化患者就用药48周前后治疗效果及肝功能改变进行分析观察,在治疗前后对比效果并进行评价。结果 2组患者丙氨酸氨基转移酶(ALT)、血清蛋白(ALB)、总胆红素(TBLL)与透明质酸(HA)治疗前后差异有统计学意义(P<0.05)。结论针对低病毒乙型肝炎病毒相关活动性肝硬化患者采用阿德福韦酯治疗可有效改善患者肝功能,较好的病毒及生化学答应,不良反应轻,值得在临床上推广应用。 Objective To investigate the therapeutic effects of adefovir dipivoxil in patients with active low-viral load hepatitis B before and after active treatment. Methods From August 2012 to August 2013, 100 cases of hepatitis B cirrhosis patients admitted to Department of Gastroenterology, Affiliated People’s Hospital of our University were analyzed about the treatment effect and the changes of liver function before and 48 weeks after treatment. The comparison results before and after treatment And evaluate it. Results The ALT, ALB, TBLL and HA before and after treatment were significantly different between the two groups (P <0.05). Conclusions Adefovir dipivoxil treatment for active hepatitis B virus-associated active cirrhosis patients can effectively improve liver function, better virus and biochemical response, light adverse reactions, and worth popularizing in clinic.