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目的探讨包括苯并卟啉衍生物单酸环Ａ（ＢｐＤＭＡ）在内的８种苯并卟啉衍生物对小鼠肉瘤１８０的光动力治疗效果。方法荷肉瘤１８０小鼠分别按６μｇ／ｇ和２μｇ／ｇ的剂量静脉注射ＢｐＤ，１．５ｈ后用波长６３０ｎｍ的铜蒸气染料激光照射，激光功率密度为１８０ｍＷ／ｃｍ２，照射时间２０ｍｉｎ，每次光剂量１５０Ｊ／ｃｍ２。同时设相同剂量血卟啉衍生物（ＨｐＤ）对照组和空白对照组。结果６μｇ／ｇ剂量时，８种ＢｐＤ中有５种对小鼠肉瘤１８０的治愈率接近或超过４０％，明显高于ＨｐＤ的１０％。其中ＢｐＤＭＡ的疗效最好，治愈率高达８０％，以下依次为８甲氧乙基ＢｐＤ（６０％）、３甲氧乙基ＢｐＤ（５０％）、８羟乙基ＢｐＤ（４０％）和ＢｐＤ单酸环Ｂ（３７５％）。２μｇ／ｇ剂量时，这５种ＢｐＤ对肉瘤１８０的抑制率分别为７７．５％、７０．８％、６８．２％、５０．９％和４５７％。与ＨｐＤ对照组比较，治疗后平均瘤重的差异均有非常显著意义（Ｐ＜０．０１）。结论ＢｐＤ是一类疗效较好的光化学治疗药物，为研究开发光敏剂新药提供了思路。
Objective To investigate the photodynamic therapy effects of eight benzoporphyrin derivatives including benzoporphyrin derivative mono-acid ring A (BpD-MA) on mouse sarcoma 180. Methods The sarcoma 180 mice were injected with BpD intravenously at a dose of 6 μg/g and 2 μg/g respectively. After 1.5 hours, they were irradiated with a copper vapor dye laser with a wavelength of 630 nm. The laser power density was 180 mW/cm2, and the irradiation time was 20 min. Dosage 150J/cm2. At the same time, the same dose of hematoporphyrin derivative (HpD) control group and blank control group were set. Results At a dose of 6 μg/g, 5 out of 8 BpDs had a cure rate of approximately 40% or higher for mouse sarcoma 180, which was significantly higher than that of HpD by 10%. Among them, BpD-MA had the best curative effect, with a cure rate of 80%, followed by 8-methoxyethyl BpD (60%), 3-methoxyethyl BpD (50%), and 8-hydroxyethyl BpD (40 %) and BpD monoacid ring B (37.5%). At a dose of 2 μg/g, the inhibitory rates of these five BpDs on sarcoma 180 were 77.5%, 70.8%, 68.2%, 50.9% and 45.7%, respectively. Compared with the HpD control group, the difference in average tumor weight after treatment was significant (P<0.01). Conclusion BpD is a kind of photochemotherapeutic drug with good curative effect, which provides the idea for the research and development of new drugs for photosensitizers.