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癲痫是一种反复发作的慢性病,除病因治疗外,不论原发或继发癫痫均需要长期服用抗癫痫药物治疗。抗癫痫药物很多,目前用多种药物联合治疗极为盛行。但很多研究表明单种药物治疗优点多,可加第二种药物。但不宜使用两种在化学结构上属同一类的药物,更禁忌两种以上的药物联合使用。因为药物代谢率的个体差异大,而很多药物有非线性药理动力学的特征,其血浓度随剂量增大而不成比例增加,半衰期又随剂量而改变,如苯妥英钠(DPH);有的药物的治疗剂量和中毒剂量很接近。因此对抗癫痫药物血清浓度的测定是很重要的。
Epilepsy is a recurrent chronic disease, in addition to the cause of treatment, regardless of primary or secondary epilepsy require long-term use of antiepileptic drugs. A lot of anti-epileptic drugs, the current combination of multiple drugs is extremely popular. However, many studies have shown that single drug treatment more advantages, you can add a second drug. However, it is not appropriate to use two kinds of drugs that belong to the same type in the chemical structure. It is more forbidden to use more than two kinds of drugs together. Because of the large individual differences in drug metabolism rates, many drugs are characterized by non-linear pharmacokinetic kinetics. Their blood concentrations increase disproportionately with increasing dose, and their half-lives change with dose, such as phenytoin sodium (DPH); some drugs The therapeutic dose and poisoning dose is very close. Therefore, antiepileptic serum concentration determination is very important.