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目的:探讨对相对固定人群每年定期进行HPV检测及宫颈液基细胞检查(LCT)在宫颈癌防治过程中的作用。方法:自2003～2010年对深圳某单位适龄女性员工每年定期进行HPV检测及液基细胞检查,有HPV阳性及液细胞异常者进行阴道镜检查,对可疑病例行阴道镜下活检病理组织学确诊。结果:(1)高危HPV感染率在从2003年的18.0%逐年降低到2010年的7.0%;(2)CIN、宫颈癌发生率从2003年的5.66%逐年降低到2010年的0.06%;(3)2009年HPV感染持续阳性者占感染人群的38.4%,自然转阴率61.6%,2010年新感染率占感染人群的49.4%。群体新感染率3.48%结论:在健康人群中定期进行HPV和宫颈液基细胞(TCT)筛查,对降低HPV感染率,预防宫颈癌发生有着十分重要意义。
Objective: To investigate the effect of routine HPV testing and LCT on the prevention and treatment of cervical cancer in relatively fixed population. Methods: From 2003 to 2010, we conducted regular HPV testing and liquid-based cytology examinations on a regular basis among women of the same age in Shenzhen. Colposcopy was performed on those with HPV positive and abnormalities of liquid cells. The suspected cases were diagnosed by colposcopy biopsy . Results: (1) The rate of high-risk HPV infection decreased from 18.0% in 2003 to 7.0% in 2010; (2) The incidence of CIN and cervical cancer decreased from 5.66% in 2003 to 0.06% in 2010; 3) Persistent HPV infection in 2009 accounted for 38.4% of the infected population, with a natural conversion rate of 61.6%. In 2010, the new infection rate accounted for 49.4% of the infected population. New infection rate of 3.48% of the population Conclusion: Regular screening of HPV and cervical liquid-based cells (TCT) in healthy population is very important for reducing the HPV infection rate and preventing the occurrence of cervical cancer.