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MicroRNAs(miRNA)是一类长18～25 nt的非编码RNA,可以靶向于特异性mRNA的3′-UTR区,通过抑制mRNA的翻译或直接引起其降解来沉默对应的靶基因,从而调节各种各样的生物学过程。但是对于miRNA的表达在哺乳动物细胞中如何被调控了解还不多。
MicroRNAs (miRNAs) are a class of 18- to 25-nt non-coding RNAs that target the 3’-UTR region of specific mRNAs and regulate the target genes by silencing their translation or directly causing their degradation Various biological processes. However, there is not much understanding of how miRNA expression is regulated in mammalian cells.