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本文研究了用母亲妊娠后期接种肺炎球菌多糖菌苗方法预防新生儿侵袭性肺炎球菌感染的可行性.150名妊娠后期妇女(初产妇50名,经产妇100名)随机接种23价肺炎球菌多糖菌苗或脑膜炎球菌多糖菌苗(对照).免疫前给患疟疾和性病试验(VDRL)阳性的妇女分别用氯喹和苄星青霉素治疗.分别采集母亲静脉血样和新生儿脐带血样,并在随访期采集婴儿指尖血样.用ELISA法测定抗6个血清型(1、3、5、6、14和19F型)肺炎球菌的抗体水平.结果表明,在肺炎球菌多糖菌苗组中,妊娠妇女均能对除6型多糖外的其他5个型的多糖产生强抗体应答,其婴儿的抗肺炎球菌抗体水平亦高于对照组.脐带血中抗肺炎球菌lgG抗体水平约为母亲水平的一半,而且
This study investigated the feasibility of using a pneumococcal polysaccharide vaccine to prevent invasive pneumococcal infection in neonates during the last trimester of pregnancy.A total of 150 pregnant women (50 mothers and 100 mothers) were randomized to receive 23 pneumococcal polysaccharide Mice or meningococcal polysaccharide vaccine (control). Women immunized against malaria and venereal disease (VDRL) before immunization were treated with chloroquine and benzathine, respectively, and maternal venous blood samples and neonatal umbilical cord blood samples were collected and monitored at follow-up Antibiotics against 6 serotypes (type 1, 3, 5, 6, 14 and 19F) of pneumococci were detected by ELISA, and the results showed that in the pneumococcal polysaccharide vaccine group, both pregnant women Can produce strong antibody response to the other five types of polysaccharides except type 6 polysaccharide, and its infant’s anti-pneumococcal antibody level is also higher than that of the control group. The level of anti-pneumococcus lgG antibody in umbilical cord blood is about half that of the mother’s level,