Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation(mechanical allodynia)is commonly observed.Its origins are poorly understood and the pain is often refractory to common analgesic therapeutics.The past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain(pain arising from damage or disease of the somatosensory system).Beginning Following injury to the peripheral nerve, pain secondary to low threshold innocuous mechanical stimulation (mechanical allodynia) is commonly observed. Its origins are poorly understood and the pain is often refractory to common analgesic therapeutics. Past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain (pain arising from damage or disease of the somatosensory system) .Beginning