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从符合1982年美国风湿病协会SLE诊断标准的病例取病损区皮肤及其微血管为标本,进行光镜、电镜和免疫组织化学研究。用透射电镜首先发现SLE免疫复合物沉积的部位主要在皮肤真皮层的表面;并阐明皮肤病变损伤程度和肾脏损伤程度相一致。通过微血管病变的观察,可以了解机体内补体缺乏、微循环障碍和血液流变学的改变,对探讨发病机理、判定SLE药物疗效和预后具有重要作用。免疫荧光检验法和免疫组织化学对SLE临床诊断具有特异性。
Light microscopy, electron microscopy and immunohistochemical studies were performed on the skin and its microvessels from lesions that met the diagnostic criteria of the American College of Rheumatology in 1982. Transmission electron microscopy first found SLE immune complex deposition site mainly in the dermal layer of the surface; and clarify the extent of skin lesions and kidney damage consistent. Through the observation of microangiopathy, we can understand the body of lack of complement, microcirculation and hemorheology changes, to explore the pathogenesis, determine the efficacy and prognosis of SLE drugs play an important role. Immunofluorescence and immunohistochemistry are specific for the clinical diagnosis of SLE.