目的 :探讨NK细胞浸润与胃癌患者预后间的关系。方法 :应用免疫组化S P法对 15 9例有详细随访资料的胃癌组织进行CD5 7染色分析 ,通过NK细胞计数 ,将NK细胞浸润程度分为 3组 :NK细胞少量浸润组 (NK细胞浸润 <5 0个 ) ;NK细胞中量浸润组 (NK细胞数在 5 0～ 15 0个 )和NK细胞多量浸润组 (NK细胞数 >15 0个 ) ,使用Cox风险模型进行多因素分析。结果 :随着TNM分期的进展胃癌患者 5年生存率明显降低 (P <0 0 5 )。NK细胞多量浸润者 5年生存率高于NK细胞少量浸润者和中量浸润者 (P <0 0 5 ) ,同时对TNM分期后发现TNMⅢ～Ⅳ期的胃癌患者中 ,NK细胞多量浸润者的 5年生存率高于NK细胞少量浸润者和中量浸润者。多因素Cox风险模型分析发现影响胃癌患者总体生存率的因素有 :TNM分期 ,NK细胞浸润数量 ,肿瘤分化程度和肿瘤大小。结论 :胃癌患者肿瘤细胞间NK细胞多量浸润与较好的预后有关 ,并且肿瘤细胞间NK细胞浸润数量可作为判定胃癌预后的一个指标 ,特别是TNMⅢ～Ⅳ期的胃癌患者 Objective: To investigate the relationship between NK cell infiltration and prognosis of gastric cancer. Methods: Fifty-nine gastric cancer tissues with detailed follow-up data were analyzed for CD5 7 staining by immunohistochemical SP method. The degree of NK cell infiltration was divided into three groups according to the number of NK cells: a small amount of NK cells (infiltration of NK cells < Fifty NK cells (50 to 150 NK cells) and NK NK cells (> 150 NK cells) were used for multivariate analysis using the Cox risk model. Results: With the progress of TNM staging, the 5-year survival rate of patients with gastric cancer was significantly lower (P <0.05). The 5-year survival rate of patients with large number of NK cells infiltrated was significantly higher than that of patients with small infiltrated NK cells and moderate infiltration of NK cells (P <0.05). Meanwhile, TNM stage Ⅲ-Ⅳ gastric cancer patients with large numbers of NK cells infiltrated The 5-year survival rate was higher than those with small infiltration of NK cells and infiltrated cells. Multivariate Cox risk model analysis found that factors affecting the overall survival rate of gastric cancer patients are: TNM staging, NK cell infiltration, tumor differentiation and tumor size. Conclusion: The large amount of intercellular NK cells in gastric cancer patients is associated with better prognosis, and the number of NK cell infiltration in tumor cells can be used as an index to judge the prognosis of gastric cancer, especially in gastric cancer patients with TNM Ⅲ ~ Ⅳ