论文部分内容阅读
目的 探讨子痫前期孕妇尿液中可溶性酪氨酸激酶受体(sFlt-1)/胎盘生长因子(PLGF)比值检测及其与动态血压、子宫动脉血流变化的相关关系.方法 收集2013年7月-2016年2月该院收治的孕中期子痫前期患者90例,其中轻度子痫前期52例作为轻度组,重度子痫前期38例作为重度组.另取同期在该院进行常规产检的孕中期正常孕妇50例作为正常对照组.对比各组孕妇尿液sFlt-1/PLGF比值、动态血压指标及子宫动脉血流参数水平.结果 轻度组、重度组孕妇尿液中sFlt-1/PLGF比值显著高于正常对照组孕妇,且重度组孕妇尿液中sFltt-1/PLGF比值高于轻度组(P＜0.05).轻度组、重度组孕妇的动态血压指标24h平均收缩压(SBP)、24h平均舒张压(DBP)、白天平均收缩压(dSBP)、白天平均舒张压(dDBP)、夜间平均收缩压(nSBP)、夜间平均舒张压(nDBP)水平,子宫动脉血流参数子宫动脉搏动指数(PI)、阻力指数(RI)、子宫动脉收缩期与舒张期流速比(S/D)水平均高于正常对照组孕妇,且重度组孕妇的升高程度较轻度组更明显(P＜0.05).子痫前期孕妇尿液中sFlt-1/PLGF与动态血压指标、子宫动脉血流参数水平呈正相关.结论 尿液中sFlt-1/PLGF比值可辅助诊断子痫前期,且其比值与孕妇动态血压、子宫动脉血流参数水平均直接相关,可作为病情严重程度判断的间接指标.“,”Objective To explore the relationships between soluble tyrosine kinase receptor-1 (Flt-1) /placental growth factor (PL-GF) ratio in urine and ambulatory blood pressure,changes of uterine artery blood flow in pregnant women with preeclampsia.Methods Ninety patients with preeclampsia during the second trimester of pregnancy treated in the hospital from July 2013 to February 2016 were collected and divided into mild preeclampsia group (52 cases) and severe preeclampsia group (38 cases).Fifty normal pregnant women during the second trimester of pregnancy receiving routine prenatal examination in the hospital during the same period were selected as normal control group.The observation indexes included sFlt-1/PLGF ratio in urine,ambulatory blood pressure indexes,and uterine artery blood flow parameters,all the indexes were compared among the three groups.Results sFlt-1/PLGF ratio in urine in mild preeclampsia group and severe preeclampsia group were statistically significantly higher than those in normal control group (P＜0.05).sFlt-1/PLGF ratio in urine in severe preeclampsia group was statistically significantly higher than that in normal control group (P＜0.05).24-hour mean systolic blood pressure (SBP),24-hour mean diastolic blood pressure (DBP),day mean systolic blood pressure (dSBP),day mean diastolic blood pressure (dDBP),night mean systolic blood pressure (nSBP),night mean diastolic blood pressure (nDBP),uterine artery pulsatility index (PI),uterine artery resistance index (RI),uterine artery systolic/diastolic velocity ratio (S/D) in mild preeclampsia group and severe preeclampsia group were statistically significantly higher than those in normal control group (P＜0.05).The increasing amplitudes of the above-mentioned indexes in severe preeclampsia group were statistically significantly higher than those in mild preeclampsia group (P＜0.05).Among the pregnant women with preeclampsia,sFlt-1/PLGF ratio in urine was positively correlated with ambulatory blood pressure indexes and uterine artery blood flow parameters.Conclusion Urine sFlt-1/PLGF ratio can assist in diagnosis of preeclampsia,and it is directly related to ambulatory blood pressure and uterine artery blood flow parameters,which can be used as an indirect indicator to judge severity of the disease.