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造血干细胞的概念虽有多次改变,但干细胞的存在,已为今天许多临床的或实验的事实所证实。 1961年,Till及Meculloch报告了脾集落形成法,其后Becker证明一个集落中的所有细胞都是由一个细胞分裂增殖而来,并认为这是红细胞、粒细胞、巨核细胞系共同的多能性干细胞。随着干细胞实验研究的进展,证明了干细胞有各种成熟阶段。Pike及Robinson报告,用半固体琼脂培养基培养人类骨髓细胞时有集落形成,认为这是来源于粒细胞系干细胞的。我们应用粒细胞形成法,对慢性粒细胞
Although the concept of hematopoietic stem cells has changed several times, the existence of stem cells has been confirmed by many clinical or experimental facts today. In 1961, Till and Meculloch reported spleen colony formation, and Becker later demonstrated that all cells in a colony were derived from a single cell division and thought this was a common pluripotency of the red, granulocyte, and megakaryocytic cell lines. stem cell. With the progress of stem cell experimental research, it has been demonstrated that stem cells have various stages of maturation. Pike and Robinson reported that colonies were formed when human bone marrow cells were cultured on a semi-solid agar medium, which was thought to be derived from granulocyte stem cells. We apply granulocyte formation to chronic granulocytes