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目的:探讨糖尿病患者血浆D-二聚体与糖尿病肾病(DN)的相关性。方法:对59例2型糖尿病患者按尿微量白蛋白排泌率(UAER)分为三组,分别测定血浆D-二聚体、纤维蛋白原等。结果:DN患者随着UAER的增高,血浆D-二聚体也显著高于对照组,差异有统计学意义。结论:血浆D-二聚体是2型DN的主要危险因素之一。与尿微量白蛋白联合检测可作为DN病情进展的参考指标。
Objective: To investigate the correlation between plasma D-dimer and diabetic nephropathy (DN) in diabetic patients. Methods: 59 patients with type 2 diabetes mellitus were divided into three groups according to urinary albumin excretion rate (UAER), and plasma D-dimer and fibrinogen were measured respectively. Results: With the increase of UAER in patients with DN, plasma D-dimer was also significantly higher than the control group, the difference was statistically significant. Conclusions: Plasma D-dimer is one of the major risk factors for type 2 DN. Combined with urine microalbumin can be used as a reference for the progression of DN.