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目的研究血浆内皮素 (ET 1)和降钙素基因相关肽 (CGRP)对慢性阻塞性肺病 (COPD)的影响 ,以探讨其改变在COPD病理生理过程中的作用。方法测定 4 8例老年COPD患者及健康对照组 30例ET 1及CGRP水平 ,并将COPD组分为急性发作期 (A组 ) 34例及临床缓解期 (B组 ) 14例 ,测定A组治疗前后血浆ET 1、CGRP水平 ,以及PoO2 、SaO2 浓度。结果老年COPD组血浆ET 1(41 2 5±2 1.4 3ng L)明显高于对照组 (2 7.2 1± 12 .73ng L)老年COPD组血浆CGRP(6 7 2 6± 31.6 0ng L)明显高于对照组 (39 75± 7.85ng L) ,二者与对照组相比较 ,差异均有显著意义 (P <0 0 1)。COPDA组治疗前后血浆ET 1、CGRP比较 ,治疗后ET 1水平 (35 11± 13.0 6ng L)较治疗前降低 (6 3 4 7± 2 9.12ng L) ,差异有显著意义 ,CGRP治疗后水平 (112 4 2± 71.87ng L)较治疗前升高 (84 12± 36 .0 9ng L) ,差异有显著意义。并且ET 1水平与动脉血氧分压 (PaO2 )及血氧饱和度 (SaO2 )呈负相关 ,CGRP水平与PaO2 、SaO2 呈正相关。结论缺氧状态下的ET 1、CGRP的失衡是影响COPD的重要病理生理改变
Objective To investigate the effects of endothelin (ET 1) and calcitonin gene related peptide (CGRP) on chronic obstructive pulmonary disease (COPD) in order to explore its role in the pathophysiology of COPD. Methods Thirty ET 1 and CGRP levels were measured in 48 elderly COPD patients and healthy controls. COPD patients were divided into acute exacerbation (group A) 34 and clinical remission (group B) 14 cases. Before and after the plasma ET 1, CGRP levels, and PoO2, SaO2 concentration. Results The plasma level of ET 1 (41 2 5 ± 2 1.4 3 ng L) in the COPD group was significantly higher than that of the control group (2 7.2 1 ± 12.73 ng L). The plasma CGRP (6 7 2 6 ± 31.6 0 ng L) The control group (39 75 ± 7.85ng L), both compared with the control group, the difference was significant (P <0.01). The levels of ET 1 and CGRP in the COPDA group before and after treatment were significantly lower than those before the treatment (35 11 ± 13.0 6 ng L) after treatment (P <0.05), the difference was significant 112 4 2 ± 71.87ng L) than before treatment (84 12 ± 36 .0 9ng L), the difference was significant. ET1 level was negatively correlated with PaO2 and SaO2, while CGRP level was positively correlated with PaO2 and SaO2. Conclusion The imbalance of ET 1 and CGRP under hypoxia is an important pathophysiological change affecting COPD