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病因探讨获得性心瓣膜病可能由多种的感染原引起,但过去一向只重视“风湿”的病因,而风湿热又被认为与A族溶血性链球菌感染密切相关,故一般认为链球菌是风湿性心脏病的病原;但链球菌是否为唯一的因素,值得研究,而且其确切的发病机理尚未得到充分阐明。临床上注意到有1/3～1/2的“风湿性”心瓣膜病患者以前没有急性风湿热史。很多年轻的妇女有风湿热病史而很少或没有心脏病的证据,而很多有二尖瓣狭窄的人没有风湿病史。病毒能引起人类的心脏病已为大家所公认。近年来临床医生对病毒性心肌炎和心包炎已有所认识,但病毒性心内膜炎或心瓣膜炎的概念仍未被接受。Burch等在详细复习了链球菌与慢性心瓣膜病的关系后,认为许多心瓣膜病是由于病毒引起的。因此他们提出病毒不但能引起
Etiology explore acquired valvular heart disease may be caused by a variety of infectious agents, but in the past has always attached importance to the cause of “rheumatism”, and rheumatic fever and is considered to be closely linked to group A hemolytic streptococcus infection, it is generally believed that streptococcus is Rheumatic heart disease; but whether streptococcus is the only factor worthy of study, and its exact pathogenesis has not yet been fully elucidated. Clinically, one third to one-half of patients with “rheumatic” valvular heart disease have not previously had a history of acute rheumatic fever. Many young women have a history of rheumatic fever with little or no evidence of heart disease, and many have mitral stenosis without a history of rheumatism. The virus can cause human heart disease has been recognized by everyone. In recent years, clinicians have been aware of viral myocarditis and pericarditis, but the concept of viral endocarditis or valvular heart disease has not yet been accepted. After reviewing the relationship between streptococci and chronic heart disease, Burch et al. Concluded that many heart valvular diseases are caused by viruses. Therefore, they raised the virus not only cause