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8例慢阻肺呼吸衰竭急性发作期患者在静滴可拉明中进行16次动脉血气分析,PaCO_2降低10次,PaCO_2增高6次。PaCO_2降低组和增高组滴药前后口腔闭合压(P0.1)、每分通气量((?)E)、肺泡通气量((?)A)和 CO_2生成量((?)CO_2)的变化率即ΔP0.1%、Δ(?)E%、Δ(?)A%和Δ(?)CO_2%的差别无统计学意义。而Δ(?)A%/Δ(?)CO_2%能提示 PaCO_2%变化趋势,Δ(?)A%/Δ(?)CO_2%>1的9次 PaCO_2全部降低,△(?)A%/ΔCO_2%<1的7次中6次 PaCO_2增高。资料显示静滴可拉明时 PaCO_2的变化取决于肺泡通气量和 CO_2生成量的变化以何者为主。
Eight patients with COPD in acute exacerbation were subjected to 16 arterial blood gas analyzes in intravenous clofibrate, with PaCO 2 reduced 10 times and PaCO 2 increased 6 times. Changes of oral closure pressure (P0.1), ventilation ((?) E), alveolar ventilation (? A) and CO_2 production ((? The rate of ΔP0.1%, Δ (?) E%, Δ (?) A% and Δ (?) CO_2% of the difference was not statistically significant. While Δ (Δ) Δ% Δ Δ CO 2% can indicate the change trend of PaCO_2, the decrease of 9 times PaCO_2 of Δ (Δ) A% / Δ (CO 2%> 1) 6 times PaCO 2 increase in 7 times of ΔCO_2% <1. The data show that the change of PaCO_2 during IVR depends on the changes of alveolar ventilation and CO 2 production.