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目的评价不同种类乙肝疫苗成人免疫效果和儿童加强免疫效果。方法筛选乙肝表面抗原(HBsAg)、乙肝表面抗体(抗-HBs)、乙肝核心抗体(抗-HBc)阴性的学龄前儿童及大学生,按照0、1、6个月程序接种4种疫苗,采用血清流行病学的方法,对其免疫效果进行比较。结果接种不同种类基因乙肝疫苗都能获得较理想的免疫效果,平均抗-HBs阳性率在95.00%以上,平均GMC1336.58 mIU/mL。对既往接种过乙肝疫苗且目前HBV感染指标阴性的儿童分别加强接种不同种类乙肝疫苗,抗-HBs阳性率均在96.00%以上,平均GMC为966.50 mIU/mL。结论接种4种不同的乙肝疫苗均有较好的免疫效果。
Objective To evaluate the effects of different types of hepatitis B vaccine on adult immunity and children’s immune enhancement. Methods The screening of HBsAg, HBsAg, HBc-negative preschool-age children and college students, according to 0, 1, 6 months vaccination of four kinds of vaccine, using serum Epidemiological methods to compare their immune effects. Results Hepatitis B vaccination with different kinds of gene could achieve better immune effect. The average positive rate of anti-HBs was above 95.00% with an average GMC of 1336.58 mIU / mL. The positive rate of anti-HBs positive rate of anti-HBs was over 96.00% for children who had been vaccinated with hepatitis B vaccine and whose current HBV infection was negative. The average GMC was 966.50 mIU / mL. Conclusion Inoculation of 4 different hepatitis B vaccines has a better immune effect.