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目的:探讨难治性复发性急性白血病(AL)的治疗方法。方法:13例难治性复发性AL用吡喃阿霉素(THP)、安吖啶(AMSA)、阿糖胞苷(Ara-C)组成的TAA方案联合阿米福汀(AMF)方案治疗。THP 10 mg／d,第1-3天,静滴;AMSA 75 mg／d,第1-3天,静滴;Ara-C 200 mg／d,第1-7天,静滴。AMF 400-800 mg／d,第1-5天,静滴。结果:完全缓解(CR)7例(53．8％),部分缓解(PR)3例(23．1％),总有效率为76．9％。结论:阿米福汀对化疗所致机体的损害有保护作用, TAA方案联合AMF是治疗难治性复发性AL的有效方法。
Objective: To explore the treatment of refractory recurrent acute leukemia (AL). Methods: Thirteen refractory relapsed AL patients were treated with TAA regimen consisting of THP, AMSA and Ara-C combined with AMF regimen . THP 10 mg / d, days 1-3, intravenous; AMSA 75 mg / d, days 1-3, intravenous; Ara-C 200 mg / d, days 1-7. AMF 400-800 mg / d, days 1-5, intravenous infusion. Results: 7 cases (53.8%) of complete remission (CR), 3 cases (23.1%) of partial remission (PR), the total effective rate was 76.9%. CONCLUSION: Amifostine has a protective effect on the injury caused by chemotherapy. TAA regimen combined with AMF is an effective method for the treatment of refractory recurrent AL.