目的重症恶性疟疾病情重，变化快，并发症多，患者若抢救不及时常可导致死亡，为观察疗效，总结121例重症恶性疟患者的临床抢救情况。方法用国产青蒿琥酯、蒿甲醚和法国产Quinimax配合一系列综合治疗。结果抢救121例重症恶性疟疾患者，共治愈103例（85．1％），死亡18例（14．9％）。结论早期诊断，积极预防并发症是降低死亡率的主要环节。 Objective Severe falciparum malaria is seriously ill, rapidly changing and has many complications. If the patients are not rescued in time, they may often lead to death. To observe the curative effect, 121 cases of severe malaria were reviewed. Methods domestic artesunate, artemether and French Quinimax with a series of comprehensive treatment. Results Rescue 121 patients with severe falciparum malaria, a total of 103 cases were cured (85.1%), 18 patients died (14.9%). Conclusion Early diagnosis and active prevention of complications are the main steps to reduce mortality.