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目的：观察前列腺Ｅ_1与弥可保联合应用对糖尿病周围神经病变的疗效。方法：８７例糖尿病周围神经病变患者随机分组对照观察，治疗组４９例给予前列腺素Ｅ_1２００ μｇ静脉点滴每日一次，同时每日肌注弥可保 ５００μｇ，共 ６周；对照组 ３８例，单用弥可保肌注，每日５００μｇ共６周。结果：治疗组痛觉过敏及感觉减退，有效率达６５％和７９％，明显高于对照组的４４％和５６％，Ｐ＜０．０５；神经传导速度改善的有效率也有一定程度的提高，Ｐ＜０．０５。结论：前列腺素Ｅ_1与弥可保联合应用可明显提高对糖尿病周围神经病变的疗效。
Objective: To observe the efficacy of combined application of prostate E_1 and methycobal on diabetic peripheral neuropathy. Methods: Eighty-seven patients with diabetic peripheral neuropathy were randomly divided into two groups. 49 cases in the treatment group were given intravenous injection of prostaglandin E-1200 μg intravenously once daily for 5 weeks, Mi Kebao intramuscular injection, 500μg daily for 6 weeks. Results: The treatment group had hyperalgesia and sensory loss, the effective rates were 65% and 79%, which were significantly higher than those in the control group (44% and 56%, P <0.05). The effective rate of nerve conduction velocity improvement was also improved to a certain extent, P <0.05. Conclusion: The combination of prostaglandin E_1 and methycobal can significantly improve the efficacy of diabetic peripheral neuropathy.