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目的分析四川省噬菌体6型霍乱的流行及病原学特征,为制定防控对策提供依据。方法根据1998-2001年省噬菌体6型霍乱流行病学个案调查表、专题调查、实验室检验鉴定结果以及各地霍乱防治工作总结等资料,进行描述流行病学分析和实验室结果分析。结果1998-2008四川省出现首例噬菌体6型霍乱病例,1998-2001年累计报告6b型霍乱2 239例,死亡100例。6b型霍乱年平均发病率为0.66/10万,病死率为4.47%。疫情波及全省5个市(州)的20个县(区)。分子生物学试验:噬菌体分型6型菌株与同期流行的1型菌株完全一致,具有流行株的分子特征。结论噬菌体6型霍乱菌株具有引起霍乱流行的能力,且病死率较高。
Objective To analyze the epidemiological and etiological characteristics of phage type 6 cholera in Sichuan Province and provide evidence for the development of control strategies. Methods Epidemiological analysis and laboratory analysis were conducted based on the epidemiological case list of cholerae of bacteriophages from 1998 to 2001, special investigations, laboratory tests and identification results and the prevention and treatment work of cholera in different areas. Results The first case of bacteriophage type 6 cholera occurred in Sichuan province from 1998 to 2008. A total of 2 239 cases of type 6b cholera were reported from 1998 to 2001, with 100 deaths. The average annual incidence of type 6b cholera was 0.66 / 100,000 and the case fatality rate was 4.47%. The outbreak spread to 20 counties (districts) in 5 cities (prefectures) across the province. Molecular Biology Test: Bacteriophage Typing Type 6 strains are exactly the same as the type 1 strains prevailing in the same period, and have the molecular characteristics of the epidemic strains. Conclusion Bacteriophage type 6 cholera strains have the ability to cause cholera epidemic, and the mortality rate is high.