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1临床资料患者女,81岁,主因“发现白细胞减少4月”入院。4月前因泌尿系感染于我院查血常规示:WBC 1.0×10~9·L~(-1),N0.3×10~9·L~(-1),Hb 97 g·L~(-1),Plt 89×10~9·L~(-1),于我院血液科住院查骨穿示骨髓增生低下,后多次复查WBC示N波动于0.5×10~9·L~(-1)左右,考虑为粒细胞缺乏症、Felty综合征,查血常规示WBC 0.8×10~9·L~(-1),N 0.3×10~9·L~(-1),予重组人粒细胞集落刺激因子(rhG-CSF,商品名:洁欣中凯生物制药,批号:20090202)150μg ih后约半小时患者出现咳嗽、乏力、恶心、呕吐胃内容物,无发热,无皮疹,复查WBC
1 Clinical data The patient female, 81 years old, was mainly diagnosed with “a leukopenia” of 4 months. 4 months before the routine examination of blood in our hospital due to urinary tract infection: WBC 1.0×10~9·L~(-1), N0.3×10~9·L~(-1), Hb 97 g·L~ (-1), Plt 89×10~9·L~(-1), bone marrow biopsy in the Department of Hematology of our hospital showed low bone marrow hyperplasia, followed by repeated WBC showed that N fluctuates at 0.5×10~9·L~ (-1) Left and right, considering agranulocytosis, Felty syndrome, blood routine examination showing WBC 0.8×10~9·L~(-1), N 0.3×10~9·L~(-1), Recombinant human granulocyte colony-stimulating factor (rhG-CSF, trade name: Jiexin Zhongkai Biopharmaceutical, Lot No.: 20090202) Approximately half an hour after 150 μg ih, the patient developed cough, fatigue, nausea, vomiting stomach contents, no fever, no rash , Review WBC