淋巴瘤的典型临床表现是无痛性、进行性淋巴结肿大，但在临床上常遇到淋巴结不肿大的结外淋巴瘤，其中以皮肤病变为首发症状占结外淋巴瘤约10％[1]，由于淋巴结不肿大，而表现为皮肤的改变，临床上常造成误诊，延误治疗[2]。本文以苹样肉芽肿（MF）和Sezary综合征（SS）为中心 The typical clinical manifestations of lymphoma are painless, progressive lymphadenopathy, but often encountered in clinical lymph node metastasis of extranodal lymphoma, of which the first symptom of skin lesions account for about 10% of extranodal lymphoma [[ 1], because the lymph nodes are not enlarged, but the performance of the skin changes, clinical misdiagnosis often occurs, delaying treatment [2]. This article focuses on granuloma (MF) and Sezary syndrome (SS)