P3-1 Analysis on multiple SNPs of MPO to screen the genetic marker associated with acute leukemia in Chinese Han population ZHANG Juan, ZHU Fang-Yan, PU Yue-Pu, YIN Li-Hong(Department of Occupational and Environmental Health, School of Public Health, Southeast University, Nanjing 210009, ChinaAbstract:Myeloperoxidase (MPO) is an important metabolizing enzyme involved in oxidative stress response with some environmental carcinogens including benzene which is associated with bone marrow toxicity and leukemia after chronic exposure. The purpose of this study was to explore the genetic markers associated with acute leukemia from multiple single nucleotide polymorphisms (SNPs) of MPO in Chinese Han population. A case-control study was conducted, 134 patients with adult acute leukemia as a case group and 187 cancer-free subjects as a control group. Nine SNPs in promoter and exon which were probable markers related to the gene function and appearance of leukemia were selected. P3-1 Analysis on multiple SNPs of MPO to screen the genetic marker associated with acute leukemia in Han population ZHANG Juan, ZHU Fang-Yan, PU Yue-Pu, YIN Li-Hong (Department of Occupational and Environmental Health, School of Public Health, Southeast University, Nanjing 210009, China Abstract: Myeloperoxidase is an important metabolizing enzyme involved in oxidative stress response with some environmental carcinogens including benzene which is associated with bone marrow toxicity and leukemia after chronic exposure. The purpose of this study was to explore the genetic markers associated with acute leukemia from multiple single nucleotide polymorphisms (SNPs) of MPO in Chinese Han population. A case-control study was conducted, 134 patients with adult acute leukemia as a case group and 187 cancer-free subjects as a control group. Nine SNPs in promoter and exon which were probable markers related to the gene function and appearance of leukemia were selected.