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目的探讨兰索拉唑治疗急性胰腺炎的临床效果以及对血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的影响。方法 72例急性胰腺炎患者按照随机、自愿的原则分为对照组和观察组,每组36例。两组患者均给予外科常规保守治疗,对照组患者在常规治疗基础上给予泮托拉唑,观察组在常规治疗基础上给予兰索拉唑,观察6 d。比较两组患者的治疗效果和治疗前后血清TNF-α和IL-6的变化。结果观察组总有效率明显高于对照组,差异有统计学意义(94.4%VS 75.0%,P<0.05)。治疗后两组患者血清TNF-α和IL-6较治疗前相比均明显下降,且观察组下降更为明显,差异有统计学意义(P<0.05)。结论兰索拉唑治疗急性胰腺炎患者临床效果优于泮托拉唑,可以明显降低患者血清中TNF-α和IL-6水平,值得推广应用。
Objective To investigate the clinical efficacy of lansoprazole in the treatment of acute pancreatitis and its effect on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Methods 72 patients with acute pancreatitis were randomly divided into control group and observation group according to the principle of randomness and voluntariness, 36 cases in each group. Patients in both groups were given conventional conservative treatment. Patients in the control group were treated with pantoprazole on the basis of routine treatment. The observation group was treated with lansoprazole on the basis of routine treatment for 6 days. The therapeutic effects of two groups were compared before and after treatment with changes of serum TNF-αand IL-6. Results The total effective rate in the observation group was significantly higher than that in the control group (94.4% VS 75.0%, P <0.05). Serum levels of TNF-α and IL-6 in the two groups after treatment were significantly lower than those before treatment, and the decrease in the observation group was more significant (P <0.05). Conclusions Lansoprazole is more effective than pantoprazole in the treatment of acute pancreatitis. It can significantly reduce the levels of TNF-α and IL-6 in serum of patients and is worthy of wide application.