The in-situ post-embolization fluorescence-guided hepatectomy for hepatocellular carcinoma(HCC)requires precise embolic formulation that meets both preoperative and intraoperative needs of hepatobiliary surgeons.In this Editorial,we highlight the development of Superstable Homogeneous Iodinated Formulation Technology(SHIFT)for locoregional HCC treatment.It is believed that such an intelligent solution could resolve unmet formulation needs and make a major stride to bridge the preoperative gap of precision hepatectomy.