内源性神经介质去甲肾上腺素的异构体6-羟多巴胺在成年人可选择性地和可逆地引起交感神经末梢变性(化学性交感神经切除)。作者给61例63眼开角型青光眼病人结膜下注射6-羟多巴胺(6-hydroxydopamine)合并点肾上腺素眼药水观察其疗效。61例中男性39例女性22例,年龄36～80岁。作者用下列标准选定病例:①有白内障用缩瞳剂则视力下降者,②不能耐受1%而能耐受0.25%肾上腺素者,③不能耐受碳酸酐酶抑制剂者,④高度近视不适当地用强缩瞳剂有引起视网膜脱离之可能者,⑤对其他疗法失败者。病人分3组以同样方法进行治疗。治疗前均做全面眼科检查并测定脉搏、血压、呼吸。 6-羟多巴胺治疗前2-3天双眼停点肾上腺素眼药水以避免和6-羟多巴胺竞争,特别是防止 Endogenous neurotransmitter norepinephrine, an isomer of 6-hydroxydopamine, induces sympathetic nerve terminal degeneration (chemical sympathectomy) in adults selectively and reversibly. The authors evaluated the efficacy of 6-hydroxydopamine combined with epinephrine eye drops in 61 patients with open-angle glaucoma63 eyes. In 61 cases, 39 males and 22 females were aged 36 to 80 years old. The authors selected patients with the following criteria: ① cataract with miosis agent decreased vision, ② can not tolerate 1% and 0.25% adrenaline tolerance are tolerant ③ carbonic anhydrase inhibitors can not tolerate ④ high myopia Improper use of strong miosis agents can cause retinal detachment possible, ⑤ other treatment failure. The patients were divided into 3 groups and treated in the same way. Before treatment, a comprehensive eye examination and determination of pulse, blood pressure, breathing. Dose of adrenaline eye drops 2-3 days prior to 6-hydroxydopamine treatment to avoid competition with 6-hydroxydopamine, and in particular to prevent