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目的:探讨小剂量米非司酮与左旋18-甲基炔诺酮单方用于紧急避孕的有效性和可接受性。方法:房事后服米非司酮10mg,12小时后服安慰剂一片。房事后服左旋18-甲基炔诺酮0.75mg,间隔12小时再服1次。两种药物外形一致,采用双盲法给药。结果:两药均取得满意避孕效果。但就副反应而言,米非司酮为优,两组发生率差异有显著性(u=4.88,P<0.01)。两药对缩短月经周期的机率无显著性差异(P>0.05),对延长月经周期者米非司酮明显多于左旋18-甲基炔诺酮(u=6.66,P<0.01)。结论:小剂量米非司酮可有效地阻止非意愿妊娠,且服用方便,副作用小。
Objective: To investigate the efficacy and acceptability of low-dose mifepristone combined with levonorgestrel 18-norethindrone for emergency contraception. Method: room after taking mifepristone 10mg, placebo after 12 hours. Room after-hours levodropropylene-18-norgestrel 0.75mg, an interval of 12 hours before serving 1 times. The two drugs have the same appearance and are administered by double-blind method. Results: Two drugs have achieved satisfactory contraceptive effect. However, in terms of side effects, mifepristone is superior, the difference between the two groups was significant (u = 4.88, P <0.01). There was no significant difference between the two drugs in shortening the menstrual cycle (P> 0.05). Mifepristone was more effective than levonorgestrel in prolonging the menstrual cycle (u = 6.66, P <0.01). Conclusion: Low dose mifepristone can effectively prevent unwanted pregnancy, and it is easy to take and its side effects are small.