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比较国产乙肝基因重组疫苗和血源疫苗免疫效果。用乙肝基因重组疫苗接种 47人 ,接种剂量 5 μg× 3 ,乙肝血源疫苗接种 74人 ,接种剂量 10 μg× 3 ;均按 0 ,1,2月程序接种 ;以SPRIA检测免疫对象HBV血清学标志物。结果 ,两组接种对象均未出现严重的副反应 ;完成 3针免疫接种后 6个月时 ,基因重组疫苗组抗 HBs阳转率 ( 44 7% )显著小于血源疫苗组阳转率 ( 98 7% ) ;基因重组疫苗组抗 HBsS/N值显著小于血源疫苗组。结果提示国产乙肝基因重组苗安全性是好的 ,但免疫效果较血源疫苗差。
Comparison of domestic hepatitis B gene recombinant vaccine and blood vaccine immune effect. Inoculated with hepatitis B gene recombinant vaccine 47, inoculation dose of 5 μg × 3, hepatitis B blood donor vaccination 74, inoculation dose of 10 μg × 3; were vaccinated according to 0, 1, 2 months; SPRIA detection of HBV serology landmark. As a result, no severe adverse reactions were observed in both vaccination groups. At 6 months after completion of the 3-dose immunization, the positive rate of anti-HBs (44 7%) in the recombinant vaccine group was significantly lower than that in the blood-borne vaccine group (98 7%). The anti-HBsS / N value of recombinant DNA vaccine group was significantly lower than that of the blood-borne vaccine group. The results suggest that the safety of domestic hepatitis B recombinant vaccine is good, but the immune effect is worse than that of the blood-borne vaccine.