人抗狂犬病免疫球蛋白（HRIG）因价格昂贵而在一些狂犬病流行的发展中国家得不到广泛应用。泰国红十字会国立血液中心（NBC）和Queen Saovabha Memorial研究所（QSMI）用进口组织培养狂犬病疫苗免疫志愿者,用其免疫血清生产了一批HRIG。其生产过程为:通过Cohn冷乙醇法从血浆中分离出球蛋白,再进行纯化和冻干浓缩。成品中狂犬病中和抗体滴度超过150IU/ml。这种 Human anti-rabies immunoglobulin (HRIG) is not widely used in some rabies-endemic developing countries due to its high price. The Thai Red Cross National Blood Center (NBC) and Queen Saovabha Memorial Institute (QSMI) vaccinated volunteers with rabies vaccines using imported tissue to produce a batch of HRIGs with their immune sera. The production process is as follows: the globulin is separated from the plasma by Cohn cold ethanol method, and then purified and lyophilized to concentrate. The rabies neutralizing antibody titer in the finished product exceeded 150 IU / ml. This