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为探讨缺乏系限抗原表达急性白血病的细胞起源，采用碱性磷酸酶抗碱性磷酸酶免疫酶法（ＡＰＡＡＰ），分析了２５例免疫学无法分型的急性白血病化疗后或复发后细胞表面标记的动态变化。结果：７例单纯表达ＣＤ３８抗原者，其中２例化疗后、３例复发后表达了Ｔ细胞标记；４例单纯表达ＣＤ９抗原者，化疗后或复发后均表达了Ｂ细胞标记；６例单纯表达ＨＬＡ－ＤＲ抗原者，化疗或复发后各有２例表达了Ｂ细胞标记；４例表达ＣＤ３８和ＨＬＡ－ＤＲ抗原者，各有１例化疗或复发后分别表达了Ｂ或Ｔ细胞标记；其余４例无任何分化抗原表达者，化疗后各有１例分别表达了Ｔ和Ｂ细胞标记。细胞表面标记的变异反映了白血病细胞克隆的演化和进展，动态研究有助于白血病细胞起源的判断
In order to investigate the origin of cells lacking the limited antigen expression in acute leukemia, alkaline phosphatase-resistant alkaline phosphatase (APAAP) was used to analyze the cell surface markers of 25 cases of acute leukemia that could not be classified by immunology or after chemotherapy Dynamic changes. Results: Seven cases of CD38 antigen were expressed only in two of them, and three of them showed T cell markers after recurrent chemotherapy. Four of them expressed CD9 antigen alone or after chemotherapy, and all of them expressed B-cell markers after chemotherapy or 6 cases of simple expression HLA-DR antigen, 2 cases after chemotherapy or relapse respectively expressed B cell marker; 4 cases expressed CD38 and HLA-DR antigen, each had 1 case of B or T cell marker after chemotherapy or relapse; the other 4 Cases without any differentiation of antigen expression, chemotherapy, 1 case of each expressed T and B cell markers. Variation in cell surface markers reflects the evolution and progression of leukemic cell clones, and dynamic studies contribute to the judgment of the origin of leukemia cells