Synthesis, Crystal Structure and Antibacterial Activity of Two Hydrazones Derived from 2-Fluorobenzh

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Two new Schiff base benzoyl hydrazone compounds, C14H10FN3O3 (Ⅰ) and C14H10F2N2O (Ⅱ), have been synthesized and characterized by elemental analysis, IR, UV and X-ray single-crystal diffraction. Both compounds crystallize in monoclinic, space group P21/c with a = 7.0514(14), b = 25.928(5), c = 7.7099(15), β = 111.823(2)°, V = 1308.6(4)3, Z = 4, C14H10FN3O3, Mr = 287.25, Dc = 1.458 g/cm3, μ(MoKα) = 0.115 mm-1, F(000) = 592, the final R = 0.0841 and wR = 0.2489 for 1901 observed reflections (I > 2σ(I)) for I; a = 11.232(3), b =12.735(4), c = 8.612(2) , β = 90.869(3)°, V = 1231.7(6)3, Z = 4, C14H10F2N2O, Mr = 260.24, Dc = 1.403 g/cm3, μ(MoKα) = 0.111 mm-1, F(000) = 536, the final R = 0.0453 and wR = 0.1085 for 1317 observed reflections (I > 2σ(I)) for Ⅱ. The antibacterial activities of both compounds against two bacteria were first studied and one compound showed considerable antibacterial activity against K. Pneumonia and S. aureus. Two new Schiff base benzoyl hydrazone compounds, C14H10FN3O3 (I) and C14H10F2N2O (II), have been synthesized and characterized by elemental analysis, IR, UV and X-ray single-crystal diffraction. Both compounds crystallize in monoclinic, space group P21 / c with = 7.0514 (14) b = 25.928 (5) c = 7.7099 (15) β β = 111.823 (2) ° V = 1308.6 (4) 3 Z = 4 C14H10FN3O3 Mr = 287.25, D = 1.458 g / cm3, μ (MoKα) = 0.115 mm -1, F (000) = 592, the final R = 0.0841 and wR = 0.2489 for 1901 observed reflections (I> 2σ (I)) for I; a = 11.232 (3) b = 12.735 (4) c = 8.612 (2) β β = 90.869 (3) ° V = 1231.7 (6) 3 Z = 4 C14H10F2N2O Mr = 260.24 Dc = 1.403 the final R = 0.0453 and wR = 0.1085 for 1317 observed reflections (I> 2σ (I)) for Ⅱ. The antibacterial activities of both (MoKα) = 0.111 mm -1, F compounds against two bacteria were first studied and one compound showed considerable antibacterial activity against K. pneumonia and S. aureus.
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