鳞癌是人类常见恶性肿瘤之一,但同样分化程度的不同肿瘤是由异源性的肿瘤细胞群构成,生物学行为也不同。体外细胞培养可提供有关肿瘤细胞生长速度、化疗药物敏感试验、染色体核型异常、基因表达改变、肿瘤细胞基因组重排等体外信息,在某种程度上可预测体内肿瘤细胞的生物学行为。然而,体外培养模型缺乏宿主的生理环境,而这对于肿瘤发病的复杂过程至关重要。作者通过将人咽及喉部鳞癌组织移植于裸鼠体内的方法,比较研究原发癌与异种移植癌的组织 Squamous cell carcinoma is one of the common malignant tumors in human beings. However, different tumors with the same degree of differentiation are formed by heterogeneous tumor cell populations and have different biological behaviors. In vitro cell culture can provide in vitro information on tumor cell growth rate, chemotherapeutic drug sensitivity test, chromosomal abnormalities, gene expression changes and tumor cell genome rearrangements, to a certain extent, to predict the biological behavior of tumor cells in vivo. However, in vitro culture models lack the host’s physiological environment, which is crucial for the complex process of tumorigenesis. The author of human pharyngeal and laryngeal squamous cell carcinoma tissue transplanted in nude mice in vivo comparative study of primary cancer and xenograft cancer tissue