人们在过去很长一段时间把心室肌作为机能合胞体对待 ,认为心室肌细胞在电生理特性上是均匀一致的。随着膜片钳技术的不断成熟及应用 ,2 0世纪 80年代末期 ,人们首先注意到狗、兔心外膜下心室肌细胞有别于内、外膜心室肌细胞[1～ 3] ,进一步又发现它们不仅电生理活动不同 ,对药 People in the past for a long period of time as a syncytial cardiomyocyte body muscle, that the electrophysiological characteristics of ventricular myocytes are uniform. With the continuous development and application of patch-clamp technology, in the late 1980s, people first noticed that the subependymal ventricular myocytes of dogs and rabbits are different from the inner and outer ventricular myocytes [1-3] Also found that they not only different electrophysiological activities of the drug